Methylate | 60 Chewable Tablets

Seeking Health
Regular price £39.00 £0.00

Price reflects VAT @ 20%. Local rate VAT will be applied at checkout.

18 in stock
  • Contains active forms of folate, vitamin B12 and nine other targeted nutrients
  • Supports healthy methylation processes

Seeking Health is an American company based in Bellingham, WA that provides high-quality probiotics, supplements and multivitamin supplements.

  • High-quality products
  • Physician formulated 
  • Free of gluten, binders, additives, artificial ingredients or chemicals
  • Most products are free of  milk, eggs, fish, shellfish, tree nuts, peanuts, gluten, corn, yeast, and soy
  • Most products free of magnesium stearate
  • Most products are non-GMO
  • Manufactured in a GMP facility
  • Based on scientific research

This supplement contains active forms of folate, vitamin B12 and nine other targeted nutrients and supports healthy methylation processes.

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The targeted ingredients found in Optimal Methylate Chewable are designed to provide the following benefits and actions:*

  • Riboflavin is the primary vitamin needed to support the MTHFR enzyme. Riboflavin also helps in the recycling of glutathione (the body’s master antioxidant) along with supporting the metabolism of serotonin, epinephrine, norepinephrine, and histamine
  • Niacin helps to support histamine metabolism while providing a calming effect
  • Vitamin B6 is used in the conversion of harmful homocysteine into beneficial glutathione. Vitamin B6 also supports the production of GABA, a calming neurotransmitter
  • Folate is included in two forms: 80% as L-5-MTHF (l-methylfolate) and 20% as folinic acid. L-5-MTHF is the active methylated form of folate needed to produce the body's main methyl donor, SAMe. Folinic acid is involved in the production of energy and BH4 (an important cofactor in the body)
  • Vitamin B12 is included in three different forms: methylcobalamin to support methylation, hydroxocobalamin to balance reactive forms of nitric oxide and hydrogen sulfide, and adenosylcobalamin to support mitochondrial health and energy production
  • Choline and betaine (TMG) support the recycling of homocysteine back to methionine via the BHMT enzyme. Choline also supports the synthesis of phosphatidylcholine, which uses a large majority of the body’s methylation reactions to produce
  • Magnesium is required for the production of the body's main methyl donor, SAMe. Magnesium also supports the COMT enzyme, which can be a common culprit of methylation side effects
  • Zinc is an important cofactor for the MTR and BHMT enzymes, which helps them bind to homocysteine. Zinc also supports the reduction of excitatory NMDA activity
  • Molybdenum helps support the metabolism of sulfites, which is important if one consumes too much methylation support
  • PQQ helps support the reduction of oxidative stress, which when present, can slow the methylation cycle. PQQ is also protective of BH4, which helps support the production of neurotransmitters and the healthy form of nitric oxide
Nutritional Information
Serving Size: 1 chewable tablet
Servings Per Container: 60
  Amount Per Serving %Daily Value*
Riboflavin (as riboflavin and riboflavin 5'-phosphate sodium) 2.5 mg 192%
Niacin 2.5 mgNE 16%
Vitamin B6 (as pyridoxal 5'-phosphate and pyridoxine hydrochloride) 2.5 mg 147%
Folate [as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt and calcium folinate] 170 mcgDFE 43%
Vitamin B12 (as MECOBALACTIVE® methylcobalamin, hydroxocobalamin, and adenosylcobalamin) 38 mcg 1583%
Choline (as choline bitartrate) 25 mg 5%
Magnesium (as magnesium citrate) 25 mg 6%
Zinc (as Zinc Arginate Chelate§) 1.25 mg 11%
Molybdenum (as Molybdenum Glycinate Chelate§) 12 mcg 27%
Betaine Anhydrous (trimethylglycine) 62.5 mg *
Life PQQ (Pyrroloquinoline Quinone Disodium Salt) 1.5 mg *
* Daily Value not established.

Other Ingredients: Xylitol, natural flavors, ascorbyl palmitate, monk fruit extract, silica, salt, and malic acid.


  • Children and pregnant or lactating women should consult their healthcare professional prior to use.
  • Do not use if tamper seal is damaged.
  • Potential side effects of Methylate are often alleviated by eating food and/or taking one capsule of Niacin (50 mg).*


  • Keep closed in a cool, dry place out of reach by children.

Suggested use:-

  • Chew 1 tablet with or without food. Tablets may be cut into halves or quarters if a lesser dose is desired and taken throughout the day.
  • Do not take within 5 hours of bedtime as it may interfere with sleep.
  • Use as directed by your healthcare professional.

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